| Téléchargement | - Voir la version finale : Naturally acquired antibodies against Haemophilus influenzae type a in aboriginal adults, Canada (PDF, 910 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.3201/eid2102.140722 |
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| Auteur | Rechercher : Nix, Eli B.; Rechercher : Williams, Kylie; Rechercher : Cox, Andrew D.1; Rechercher : St. Michael, Frank1; Rechercher : Romero-steiner, Sandra; Rechercher : Schmidt, Daniel S.; Rechercher : Mccready, William G.; Rechercher : Ulanova, Marina |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Résumé | In the post-Haemophilus influenzae type b (Hib) vaccine era that began in the 1980's, H. influenzae type a (Hia) emerged as a prominent cause of invasive disease in North American Aboriginal populations. To test whether a lack of naturally acquired antibodies may underlie increased rates of invasive Hia disease, we compared serum bactericidal activity against Hia and Hib and IgG and IgM against capsular polysaccharide between Canadian Aboriginal and non-Aboriginal healthy and immunocompromised adults. Both healthy and immunocompromised Aboriginal adults exhibited significantly higher bactericidal antibody titers against Hia than did non-Aboriginal adults (p = 0.042 and 0.045 respectively), with no difference in functional antibody activity against Hib. IgM concentrations against Hia were higher than IgG in most study groups; the inverse was true for antibody concentrations against Hib. Our results indicate that Aboriginal adults possess substantial serum bactericidal activity against Hia that is mostly due to IgM antibodies. The presence of sustained IgM against Hia suggests recent Hia exposure. |
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| Date de publication | 2015-02 |
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| Maison d’édition | Centers for Disease Control and Prevention |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23001567 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | fe370596-20ec-4c5c-84b2-e796d749370b |
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| Enregistrement créé | 2017-03-07 |
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| Enregistrement modifié | 2020-05-30 |
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