| Download | - View final version: Naturally acquired antibodies against Haemophilus influenzae type a in aboriginal adults, Canada (PDF, 910 KiB)
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| DOI | Resolve DOI: https://doi.org/10.3201/eid2102.140722 |
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| Author | Search for: Nix, Eli B.; Search for: Williams, Kylie; Search for: Cox, Andrew D.1; Search for: St. Michael, Frank1; Search for: Romero-steiner, Sandra; Search for: Schmidt, Daniel S.; Search for: Mccready, William G.; Search for: Ulanova, Marina |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Abstract | In the post-Haemophilus influenzae type b (Hib) vaccine era that began in the 1980's, H. influenzae type a (Hia) emerged as a prominent cause of invasive disease in North American Aboriginal populations. To test whether a lack of naturally acquired antibodies may underlie increased rates of invasive Hia disease, we compared serum bactericidal activity against Hia and Hib and IgG and IgM against capsular polysaccharide between Canadian Aboriginal and non-Aboriginal healthy and immunocompromised adults. Both healthy and immunocompromised Aboriginal adults exhibited significantly higher bactericidal antibody titers against Hia than did non-Aboriginal adults (p = 0.042 and 0.045 respectively), with no difference in functional antibody activity against Hib. IgM concentrations against Hia were higher than IgG in most study groups; the inverse was true for antibody concentrations against Hib. Our results indicate that Aboriginal adults possess substantial serum bactericidal activity against Hia that is mostly due to IgM antibodies. The presence of sustained IgM against Hia suggests recent Hia exposure. |
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| Publication date | 2015-02 |
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| Publisher | Centers for Disease Control and Prevention |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23001567 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | fe370596-20ec-4c5c-84b2-e796d749370b |
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| Record created | 2017-03-07 |
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| Record modified | 2020-05-30 |
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