| Téléchargement | - Voir la version finale : Vitamin E for coronary bypass operations: a prospective, double-blind, randomized trial (PDF, 986 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1016/S0022-5223(94)70012-5 |
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| Auteur | Rechercher : Yau, Terrence M.; Rechercher : Weisel, Richard D.; Rechercher : Mickle, Donald A. G.; Rechercher : Burton, Graham W.1; Rechercher : Ingold, Keith U.1; Rechercher : Ivanov, Joan; Rechercher : Mohabeer, Molly K.; Rechercher : Tumiati, Laura; Rechercher : Carson, Susan |
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| Affiliation | - Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
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| Format | Texte, Article |
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| Résumé | Background: Free radical lipid peroxidation contributes to the abnormal metabolism and ventricular function frequently seen after cardiac operations. Antioxidants may improve metabolic and functional recovery. Methods: A prospective, randomized, double-blind clinical trial was conducted to determine the effects of vitamin E (alpha-tocopherol) (n = 14) or a corn oil placebo (n = 14) in patients undergoing elective coronary bypass operations. The RRR-alpha-tocopheryl acetate doubled the alpha-tocopherol levels in the heart. Myocardial metabolism and ventricular function were assessed after the operation. Results: Atrial pacing induced myocardial lactate production in the control patients but lactate consumption in the alpha-tocopherol–treated patients on bypass 25 minutes after crossclamp release. Left ventricular stroke work indices were higher, at similar ventricular volumes, in the alpha-tocopherol–treated group, which indicates improved preload recruitable stroke work, and diastolic compliance was greater 4 hours after the operation. The postoperative creatine kinase cardiac isoenzyme levels were lower in the patients who received alpha-tocopherol. Conclusions: Pretreatment with alpha-tocopherol sufficient to double the myocardial concentrations had a small but significant metabolic and functional effect after elective coronary bypass operations when compared with placebo. These results do not justify pretreatment of low-risk patients, but they do justify an evaluation in high-risk patients. |
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| Date de publication | 1994-08 |
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| Maison d’édition | Elsevier |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21276836 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | c324ee65-e345-4b0d-af16-514ff2b95085 |
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| Enregistrement créé | 2015-10-23 |
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| Enregistrement modifié | 2022-06-22 |
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