| Download | - View final version: Vitamin E for coronary bypass operations: a prospective, double-blind, randomized trial (PDF, 986 KB)
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| DOI | Resolve DOI: https://doi.org/10.1016/S0022-5223(94)70012-5 |
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| Author | Search for: Yau, Terrence M.; Search for: Weisel, Richard D.; Search for: Mickle, Donald A. G.; Search for: Burton, Graham W.1; Search for: Ingold, Keith U.1; Search for: Ivanov, Joan; Search for: Mohabeer, Molly K.; Search for: Tumiati, Laura; Search for: Carson, Susan |
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| Name affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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| Format | Text, Article |
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| Abstract | Background: Free radical lipid peroxidation contributes to the abnormal metabolism and ventricular function frequently seen after cardiac operations. Antioxidants may improve metabolic and functional recovery. Methods: A prospective, randomized, double-blind clinical trial was conducted to determine the effects of vitamin E (alpha-tocopherol) (n = 14) or a corn oil placebo (n = 14) in patients undergoing elective coronary bypass operations. The RRR-alpha-tocopheryl acetate doubled the alpha-tocopherol levels in the heart. Myocardial metabolism and ventricular function were assessed after the operation. Results: Atrial pacing induced myocardial lactate production in the control patients but lactate consumption in the alpha-tocopherol–treated patients on bypass 25 minutes after crossclamp release. Left ventricular stroke work indices were higher, at similar ventricular volumes, in the alpha-tocopherol–treated group, which indicates improved preload recruitable stroke work, and diastolic compliance was greater 4 hours after the operation. The postoperative creatine kinase cardiac isoenzyme levels were lower in the patients who received alpha-tocopherol. Conclusions: Pretreatment with alpha-tocopherol sufficient to double the myocardial concentrations had a small but significant metabolic and functional effect after elective coronary bypass operations when compared with placebo. These results do not justify pretreatment of low-risk patients, but they do justify an evaluation in high-risk patients. |
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| Publication date | 1994-08 |
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| Publisher | Elsevier |
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| Licence | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21276836 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | c324ee65-e345-4b0d-af16-514ff2b95085 |
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| Record created | 2015-10-23 |
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| Record modified | 2022-06-22 |
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