| Auteur | Rechercher : Kubler-Kielb, J.; Rechercher : Vinogradov, Evguenii; Rechercher : Chu, C.; Rechercher : Schneerson, R. |
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| Format | Texte, Article |
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| Sujet | acetylation; antigenicity; carbohydrate sequence; chain; chemistry; child; disease; glucose; glycosylation; infant; lipopolysaccharide; LPS; molecular sequence data; molecule; nuclear magnetic resonance, biomolecular; O antigens; O-specific polysaccharide; polysaccharide; serotype; Shigella flexneri; vaccines |
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| Résumé | Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. Here, we report the degree of O-acetylation and the localisation of O-acetyl groups and side-chain glucose substitution in the O-SP (scheme) in different preparations of S. flexneri type 2a LPS. [structure: see text] |
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| Date de publication | 2007-02-26 |
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| Dans | |
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| Langue | anglais |
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| Numéro du CNRC | KUBLERKIELB2007 |
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| Numéro NPARC | 9360045 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | b79cf6fb-8f33-4e2c-b0aa-a48884c26135 |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-05-10 |
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