| Author | Search for: Kubler-Kielb, J.; Search for: Vinogradov, Evguenii; Search for: Chu, C.; Search for: Schneerson, R. |
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| Format | Text, Article |
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| Subject | acetylation; antigenicity; carbohydrate sequence; chain; chemistry; child; disease; glucose; glycosylation; infant; lipopolysaccharide; LPS; molecular sequence data; molecule; nuclear magnetic resonance, biomolecular; O antigens; O-specific polysaccharide; polysaccharide; serotype; Shigella flexneri; vaccines |
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| Abstract | Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. Here, we report the degree of O-acetylation and the localisation of O-acetyl groups and side-chain glucose substitution in the O-SP (scheme) in different preparations of S. flexneri type 2a LPS. [structure: see text] |
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| Publication date | 2007-02-26 |
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| In | |
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| Language | English |
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| NRC number | KUBLERKIELB2007 |
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| NPARC number | 9360045 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | b79cf6fb-8f33-4e2c-b0aa-a48884c26135 |
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| Record created | 2009-07-10 |
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| Record modified | 2020-05-10 |
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