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Identification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in Atlantic salmon during Aeromonas salmonicida infection

Autre titreIdentification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in the liver of Atalantic salmon infected with Aeromonas salmonicida
DOITrouver le DOI : https://doi.org/10.1016/j.vetimm.2005.05.013
AuteurRechercher : 1; Rechercher : 1; Rechercher : ; Rechercher : ; Rechercher : ; Rechercher : ; Rechercher : 1; Rechercher : 1; Rechercher : 1
Affiliation
  1. Conseil national de recherches Canada. Institut des biosciences marines du CNRC
FormatTexte, Article
Sujetsoluble toll-like receptor; leucine-rich-repeats; LRR; inflammation; Atlantic salmon
Résumé
Toll-like receptors (TLRs) are involved in the innate immune response against microbial pathogens in vertebrates and insects. The extracellular region of a TLR recognizes pathogen-associated molecules, while the intracellular region initiates the signaling pathway leading to immune response. Membrane-bound TLRs have been found in most vertebrates, but few soluble forms have been reported. A novel transcript corresponding to a portion of a soluble TLR was identified in liver of infected Atlantic salmon. The complete coding sequence of this TLR was obtained and BLASTN analysis showed the highest sequence identity to a recently described full-length cDNA sequence of a soluble TLR5 from rainbow trout (GenBank Accession No.: AB062504). The deduced protein is 40% identical to the mammalian counterpart of the leucine-rich repeat (LRR)/LRR-like motifs of TLR5. Based on the structure of human TLRs, it contains 21 LRRs with conserved LxxLxLxxNx*xx*xxxxFxxL pattern. Since TLR5 is essential for the recognition of bacterial flagellins, we hypothesize that flagellin and perhaps some other pathogen-derived factors from Aeromonas salmonicida bind to this soluble TLR through an unknown binding domain within the LRR.
Date de publication
Conditions d’utilisation
  • Copyright © 2005 Elsevier B.V. All rights reserved.
Dans
  • Veterinary Immunology and Immunopathology 109, nº 1-2 (1 janvier 2006) : 183–187.
Langueanglais
Publications évaluées par des pairsOui
Numéro du CNRCNRCC 55506
1641
Numéro NPARC3538328
Exporter la noticeExporter en format RIS
Signaler une correctionSignaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrementac471292-ff11-41c9-b867-e8310357ac41
Enregistrement créé2009-03-01
Enregistrement modifié2020-04-22

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