| Téléchargement | - Voir les données supplémentaires : A mathematical model of protein subunits COVID-19 vaccines (PDF, 390 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1016/j.mbs.2023.108970 |
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| Auteur | Rechercher : Gholami, Samaneh; Rechercher : Korosec, Chapin S.; Rechercher : Farhang-Sardroodi, Suzan; Rechercher : Dick, David W.; Rechercher : Craig, Morgan; Rechercher : Ghaemi, Mohammad Sajjad1; Rechercher : Ooi, Hsu Kiang1; Rechercher : Heffernan, Jane M. |
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| Affiliation | - Conseil national de recherches Canada. Technologies numériques
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| Format | Texte, Article |
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| Sujet | protein subunit-based vaccine; SARS-CoV-2; COVID-19; adaptive immune response; Neutralizing Antibody (NAb); IgG antibody; mathematical modeling |
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| Résumé | We consider a general mathematical model for protein subunit vaccine with a focus on the MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2, and use the model to study immunological outcomes in the humoral and cell-mediated arms of the immune response from vaccination. The mathematical model is fit to vaccine clinical trial data. We elucidate the role of Interferon-𝛾 and Interleukin-4 in stimulating the immune response of the host. Model results, and results from a sensitivity analysis, show that a balance between the T𝐻 1 and T𝐻 2 arms of the immune response is struck, with the T𝐻 1 response being dominant. The model predicts that two-doses of the vaccine at 28 days apart will result in approximately 85% humoral immunity loss relative to peak immunity approximately 6 months post dose 1. |
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| Date de publication | 2023-02-10 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Autre version | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | aad1c03a-8813-44bc-b6ca-f866a9e66428 |
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| Enregistrement créé | 2023-03-17 |
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| Enregistrement modifié | 2023-03-17 |
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