| Download | - View supplementary information: A mathematical model of protein subunits COVID-19 vaccines (PDF, 390 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.mbs.2023.108970 |
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| Author | Search for: Gholami, Samaneh; Search for: Korosec, Chapin S.; Search for: Farhang-Sardroodi, Suzan; Search for: Dick, David W.; Search for: Craig, Morgan; Search for: Ghaemi, Mohammad Sajjad1; Search for: Ooi, Hsu Kiang1; Search for: Heffernan, Jane M. |
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| Affiliation | - National Research Council of Canada. Digital Technologies
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| Format | Text, Article |
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| Subject | protein subunit-based vaccine; SARS-CoV-2; COVID-19; adaptive immune response; Neutralizing Antibody (NAb); IgG antibody; mathematical modeling |
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| Abstract | We consider a general mathematical model for protein subunit vaccine with a focus on the MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2, and use the model to study immunological outcomes in the humoral and cell-mediated arms of the immune response from vaccination. The mathematical model is fit to vaccine clinical trial data. We elucidate the role of Interferon-š¾ and Interleukin-4 in stimulating the immune response of the host. Model results, and results from a sensitivity analysis, show that a balance between the Tš» 1 and Tš» 2 arms of the immune response is struck, with the Tš» 1 response being dominant. The model predicts that two-doses of the vaccine at 28 days apart will result in approximately 85% humoral immunity loss relative to peak immunity approximately 6 months post dose 1. |
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| Publication date | 2023-02-10 |
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| Publisher | Elsevier |
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| In | |
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| Other version | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | aad1c03a-8813-44bc-b6ca-f866a9e66428 |
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| Record created | 2023-03-17 |
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| Record modified | 2023-03-17 |
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