| Download | - View supplementary information: A mathematical model of protein subunits COVID-19 vaccines (PDF, 390 KiB)
|
|---|
| DOI | Resolve DOI: https://doi.org/10.1016/j.mbs.2023.108970 |
|---|
| Author | Search for: Gholami, Samaneh; Search for: Korosec, Chapin S.; Search for: Farhang-Sardroodi, Suzan; Search for: Dick, David W.; Search for: Craig, Morgan; Search for: Ghaemi, Mohammad Sajjad1; Search for: Ooi, Hsu Kiang1; Search for: Heffernan, Jane M. |
|---|
| Affiliation | - National Research Council Canada. Digital Technologies
|
|---|
| Format | Text, Article |
|---|
| Subject | protein subunit-based vaccine; SARS-CoV-2; COVID-19; adaptive immune response; Neutralizing Antibody (NAb); IgG antibody; mathematical modeling |
|---|
| Abstract | We consider a general mathematical model for protein subunit vaccine with a focus on the MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2, and use the model to study immunological outcomes in the humoral and cell-mediated arms of the immune response from vaccination. The mathematical model is fit to vaccine clinical trial data. We elucidate the role of Interferon-š¾ and Interleukin-4 in stimulating the immune response of the host. Model results, and results from a sensitivity analysis, show that a balance between the Tš» 1 and Tš» 2 arms of the immune response is struck, with the Tš» 1 response being dominant. The model predicts that two-doses of the vaccine at 28 days apart will result in approximately 85% humoral immunity loss relative to peak immunity approximately 6 months post dose 1. |
|---|
| Publication date | 2023-02-10 |
|---|
| Publisher | Elsevier |
|---|
| In | |
|---|
| Other version | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | aad1c03a-8813-44bc-b6ca-f866a9e66428 |
|---|
| Record created | 2023-03-17 |
|---|
| Record modified | 2023-03-17 |
|---|
