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Detection and identification of spirolides in Norwegian shellfish and plankton

DOITrouver le DOI : https://doi.org/10.1021/tx049706n
AuteurRechercher : ; Rechercher : 1; Rechercher : 2; Rechercher : 2; Rechercher : ; Rechercher : ; Rechercher : 2
Affiliation
  1. Conseil national de recherches Canada. Développement des cultures et des ressources aquatiques
  2. Conseil national de recherches Canada. Science des mesures et étalons
FormatTexte, Article
Sujetalgal blooms; aquaculture; bioassays; biological poisons; chemical analysis; digestive glands; glands; chromatographic techniques; jumping; lipophilic; liquid chromatography; metabolites; molecular structure; molecular weight; mussel culture; phytoplankton; poisonous organisms; plankton; public health; seafood; symptoms; shellfish; toxicity; toxicology; toxins; uptake; Bivalvia; Alexandrium ostenfeldii
Résumé
Mussels sampled in the spring of 2002 and 2003 from Skjer, a location in Sognefjord, Norway, tested positive in the mouse bioassay for lipophilic toxins. The symptoms, which included cramps, jumping, and short survival times (as low as 4 min), were not characteristic of toxins previously observed in Norway. A survey of the algae present at the aquaculture sites showed that the toxicity correlated with blooms of Alexandrium ostenfeldii. Up to 2200 cells/L were found at the peak of one bloom. In Canadian waters, this alga is known to be a producer of the cyclic imine toxins, spirolides. Analysis of mussel extracts from Skjer in the spring of 2002 and 2003, using liquid chromatography tandem mass spectrometry, revealed the presence of several new spirolides. The same compounds were also found in algal samples dominated by A. ostenfeldii, which had been sampled from Skjer in February 2003. A large-scale extraction of mussel digestive glands and chromatographic fractionation of the extracts allowed the isolation and structure elucidation of the main spirolide, 20-methyl spirolide G, with a molecular weight of 705.5. This is the first confirmed occurrence of spirolides in mussels and plankton from Norway.
Date de publication
Conditions d’utilisation
  • Copyright © 2005 American Chemical Society
Dans
  • Chemical Research in Toxicology 18, nº 3 (12 février 2005) : 509–515.
Langueanglais
Publications évaluées par des pairsOui
Numéro du CNRCNRCC 42465
1377
Numéro NPARC3538547
Exporter la noticeExporter en format RIS
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Identificateur de l’enregistrement896d6908-d066-4e25-92c7-0ce754019ad2
Enregistrement créé2009-03-01
Enregistrement modifié2020-04-07

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