| DOI | Trouver le DOI : https://doi.org/10.1007/978-94-011-0371-8_223 |
|---|
| Auteur | Rechercher : Choo, L.-P.1; Rechercher : Mansfield, J. R.1; Rechercher : Pizzi, N.1; Rechercher : Somorjai, R. L.1; Rechercher : Jackson, M.1; Rechercher : Halliday, W. C.; Rechercher : Mantsch, H. H.1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
|
|---|
| Format | Texte, Chapitre de livre |
|---|
| Conférence | 6th European Conference on the Spectroscopy of Biological Molecules, September 3-8, 1995, Villeneuve d'Ascq, France |
|---|
| Résumé | We present a new approach to the classification of infrared (IR) data of Alzheimer's diseased (AD) tissue using several multivariate (MV) methods which could potentially be used in the diagnosis of AD from autopsy tissue. Alzheimer’s disease is the most common dementing disease of adult life causing disorientation in person, time and place. The histopathological hallmarks of AD are the formation of neuritic plaques (NP) and neurofibrillary tangles (NFT) in the grey matter regions of the brain. Neuritic plaques are roughly spherical consisting of a core of amyloid peptide (βA4-amyloid peptide) surrounded by irregular, loosely arranged aggregates of neuronal and glial processes.1 Neurofibrillary tangles are bundles of abnormal filaments composed of paired helical chains of hyperphosphorylated microtubule associated protein intertwined to form paired helical filaments.1 The abnormalities of NP and NFT serve as biochemical markers amenable to characterisation by IR spectroscopy and may provide diagnostic infrared signatures of AD tissue. |
|---|
| Date de publication | 1995 |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Numéro du CNRC | NRC-IBD-421 |
|---|
| Numéro NPARC | 9721921 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 4639a76e-4577-4595-b23b-b266f7554ef6 |
|---|
| Enregistrement créé | 2009-07-17 |
|---|
| Enregistrement modifié | 2020-06-11 |
|---|
