| DOI | Resolve DOI: https://doi.org/10.1007/978-94-011-0371-8_223 |
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| Author | Search for: Choo, L.-P.1; Search for: Mansfield, J. R.1; Search for: Pizzi, N.1; Search for: Somorjai, R. L.1; Search for: Jackson, M.1; Search for: Halliday, W. C.; Search for: Mantsch, H. H.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Book Chapter |
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| Conference | 6th European Conference on the Spectroscopy of Biological Molecules, September 3-8, 1995, Villeneuve d'Ascq, France |
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| Abstract | We present a new approach to the classification of infrared (IR) data of Alzheimer's diseased (AD) tissue using several multivariate (MV) methods which could potentially be used in the diagnosis of AD from autopsy tissue. Alzheimer’s disease is the most common dementing disease of adult life causing disorientation in person, time and place. The histopathological hallmarks of AD are the formation of neuritic plaques (NP) and neurofibrillary tangles (NFT) in the grey matter regions of the brain. Neuritic plaques are roughly spherical consisting of a core of amyloid peptide (βA4-amyloid peptide) surrounded by irregular, loosely arranged aggregates of neuronal and glial processes.1 Neurofibrillary tangles are bundles of abnormal filaments composed of paired helical chains of hyperphosphorylated microtubule associated protein intertwined to form paired helical filaments.1 The abnormalities of NP and NFT serve as biochemical markers amenable to characterisation by IR spectroscopy and may provide diagnostic infrared signatures of AD tissue. |
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| Publication date | 1995 |
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| In | |
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| Language | English |
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| NRC number | NRC-IBD-421 |
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| NPARC number | 9721921 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 4639a76e-4577-4595-b23b-b266f7554ef6 |
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| Record created | 2009-07-17 |
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| Record modified | 2020-06-11 |
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