| DOI | Trouver le DOI : https://doi.org/10.1016/S0304-4165(03)00045-X |
|---|
| Auteur | Rechercher : Richards, R.C.1; Rechercher : Hudson, D.M.; Rechercher : Thibault, P.2; Rechercher : Ewart, K.V.1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Institut des biosciences marines du CNRC
- Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
|
|---|
| Format | Texte, Article |
|---|
| Sujet | Lectin superfamily; Salmo salar; Salmon serum lectin |
|---|
| Résumé | We report the cloning of four distinct cDNAs and a genomic sequence encoding a multimeric serum lectin found in the blood of Atlantic salmon (Salmo salar). The sequence variation among the cDNAs as well as genomic Southern blotting analysis revealed a multi-gene family. Expression of the salmon serum lectin (SSL) was specific to kidney, as demonstrated by RT-PCR. Analysis of the 173-amino acid sequence of SSL confirmed that it is a member of the C-type lectin superfamily. Sequence alignments and intron/exon structure of the SSL gene showed it to belong to the type VII C-type lectins, which normally bind to galactose or other ligands, whereas the SSL protein sequence contains the EPN motif of mannose-binding C-type lectins, that bind mannose or related carbohydrates. |
|---|
| Date de publication | 2003-04-07 |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro du CNRC | NRC-IMB-42376 |
|---|
| Numéro NPARC | 21272064 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 429ab822-3f14-4085-b5d7-5b614ffea93f |
|---|
| Enregistrement créé | 2014-06-16 |
|---|
| Enregistrement modifié | 2020-04-02 |
|---|
