| DOI | Resolve DOI: https://doi.org/10.1016/S0304-4165(03)00045-X |
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| Author | Search for: Richards, R.C.1; Search for: Hudson, D.M.; Search for: Thibault, P.2; Search for: Ewart, K.V.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Marine Biosciences
- National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Article |
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| Subject | Lectin superfamily; Salmo salar; Salmon serum lectin |
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| Abstract | We report the cloning of four distinct cDNAs and a genomic sequence encoding a multimeric serum lectin found in the blood of Atlantic salmon (Salmo salar). The sequence variation among the cDNAs as well as genomic Southern blotting analysis revealed a multi-gene family. Expression of the salmon serum lectin (SSL) was specific to kidney, as demonstrated by RT-PCR. Analysis of the 173-amino acid sequence of SSL confirmed that it is a member of the C-type lectin superfamily. Sequence alignments and intron/exon structure of the SSL gene showed it to belong to the type VII C-type lectins, which normally bind to galactose or other ligands, whereas the SSL protein sequence contains the EPN motif of mannose-binding C-type lectins, that bind mannose or related carbohydrates. |
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| Publication date | 2003-04-07 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRC-IMB-42376 |
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| NPARC number | 21272064 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 429ab822-3f14-4085-b5d7-5b614ffea93f |
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| Record created | 2014-06-16 |
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| Record modified | 2020-04-02 |
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