| DOI | Trouver le DOI : https://doi.org/10.1128/EC.00346-06 |
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| Auteur | Rechercher : Levitin, A.1; Rechercher : Marcil, A.1; Rechercher : Tettweiler, G.; Rechercher : Laforest, M. J.1; Rechercher : Oberholzer, U.1; Rechercher : Alarco, A. M.1; Rechercher : Thomas, D. Y.; Rechercher : Lasko, P.; Rechercher : Whiteway, M.1 |
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| Affiliation | - Conseil national de recherches Canada. Institut de recherche en biotechnologie du CNRC
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| Format | Texte, Article |
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| Sujet | candida; Candida albicans; cells; drosophila; drosophila melanogaster; genes; genome; pharmaceutical; up-regulation |
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| Résumé | We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection |
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| Date de publication | 2007 |
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| Dans | |
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| Numéro du CNRC | 47513 |
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| Numéro NPARC | 3538939 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 3cf8355d-d04e-4c6e-82c0-dec36eaa6390 |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-05-10 |
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