| DOI | Resolve DOI: https://doi.org/10.1128/EC.00346-06 |
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| Author | Search for: Levitin, A.1; Search for: Marcil, A.1; Search for: Tettweiler, G.; Search for: Laforest, M. J.1; Search for: Oberholzer, U.1; Search for: Alarco, A. M.1; Search for: Thomas, D. Y.; Search for: Lasko, P.; Search for: Whiteway, M.1 |
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| Affiliation | - National Research Council of Canada. NRC Biotechnology Research Institute
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| Format | Text, Article |
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| Subject | candida; Candida albicans; cells; drosophila; drosophila melanogaster; genes; genome; pharmaceutical; up-regulation |
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| Abstract | We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection |
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| Publication date | 2007 |
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| In | |
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| NRC number | 47513 |
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| NPARC number | 3538939 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 3cf8355d-d04e-4c6e-82c0-dec36eaa6390 |
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| Record created | 2009-03-01 |
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| Record modified | 2020-05-10 |
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