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α-tocopheryl quinone is converted into vitamin E in man

Par Conseil national de recherches du Canada

DOITrouver le DOI : https://doi.org/10.1016/S0891-5849(96)00276-6
AuteurRechercher : 1; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada
FormatTexte, Article
Sujetalpha tocopherol; alpha tocopherylquinone; free radical; anticoagulant therapy; drug blood level; drug effect; drug transformation; heart infarction; stroke; Administration, Oral; Aged; Biotransformation; Gas Chromatography-Mass Spectrometry; Intestinal Absorption; Male; Vitamin E
Résumé
The conversion of α-tocopheryl quinone into α-tocopherol in humans has been demonstrated. A male subject was given an oral dose of 400 mg of α- 3,5-[(C2H3)2]-tocopheryl quinone with an evening meal. Analysis of plasma 15 h later by lipid extraction and subsequent GC-MS single ion monitoring revealed the presence of α-[5,7(C2H3)2]-tocopherol at a concentration of 0.4 μM, representing 0.8% of the total tocopherol in the plasma sample. This experiment clearly demonstrates that orally administered α tocopheryl quinone is converted in a low overall yield to α-tocopherol in humans. The conversion to α-tocopherol of that portion of the quinone dose which was actually absorbed into the blood stream may, however, have been fairly efficient.
Date de publication
Dans
  • Free Radical Biology and Medicine 22, nº 5 (1997) : 931–934.
Langueanglais
Publications évaluées par des pairsOui
Numéro NPARC21276524
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Identificateur de l’enregistrement12bc1697-913c-47d8-998b-62a1513a6c78
Enregistrement créé2015-10-13
Enregistrement modifié2020-03-20
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