α-tocopheryl quinone is converted into vitamin E in man

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/S0891-5849(96)00276-6
AuthorSearch for: 1; Search for: 1
Name affiliation
  1. National Research Council of Canada
FormatText, Article
Journal titleFree Radical Biology and Medicine
ISSN0891-5849
Volume22
Issue5
Pages931–934
Subjectalpha tocopherol; alpha tocopherylquinone; free radical; anticoagulant therapy; drug blood level; drug effect; drug transformation; heart infarction; stroke; Administration, Oral; Aged; Biotransformation; Gas Chromatography-Mass Spectrometry; Intestinal Absorption; Male; Vitamin E
Abstract
The conversion of α-tocopheryl quinone into α-tocopherol in humans has been demonstrated. A male subject was given an oral dose of 400 mg of α- 3,5-[(C2H3)2]-tocopheryl quinone with an evening meal. Analysis of plasma 15 h later by lipid extraction and subsequent GC-MS single ion monitoring revealed the presence of α-[5,7(C2H3)2]-tocopherol at a concentration of 0.4 μM, representing 0.8% of the total tocopherol in the plasma sample. This experiment clearly demonstrates that orally administered α tocopheryl quinone is converted in a low overall yield to α-tocopherol in humans. The conversion to α-tocopherol of that portion of the quinone dose which was actually absorbed into the blood stream may, however, have been fairly efficient.
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LanguageEnglish
Peer reviewedYes
NPARC number21276524
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