| DOI | Trouver le DOI : https://doi.org/10.1016/0006-291X(86)90749-7 |
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| Auteur | Rechercher : Raptis, L.; Rechercher : Whitfield, James |
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| Format | Texte, Article |
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| Résumé | Exposure of dexamethasone-treated cells of the mT-1 line of F111 rat cells bearing a dexamethasone-inducible polyoma virus middle T (mT) antigen gene to very low concentrations of the protein kinase C-stimulating phorbol ester TPA increased the association of mT antigen with the cellular pp60c-src tyrosine protein kinase, as indicated by an increased phosphorylation of tyrosine residues of mT in mT:pp60c-src complexes precipitated from extracts of the TPA-treated cells by anti-mT antibodies. This TPA (hence probably protein kinase C)-enhanced association of mT with pp60c-src was accompanied by a large increase in the transforming ability of mT as indicated by a much enhanced ability of TPA-treated mT-1 cells producing submaximal levels of mT to proliferate while suspended in semi-solid medium and to form foci on confluent monolayers of normal F111 cells. NRCC NO: 26558. |
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| Date de publication | 1986-11-14 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | RAPTIS1986 |
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| Numéro NPARC | 9383011 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 0d9bcac2-45f9-430c-9940-60a5b7a1fabb |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-03-17 |
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