| DOI | Resolve DOI: https://doi.org/10.1016/0006-291X(86)90749-7 |
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| Author | Search for: Raptis, L.; Search for: Whitfield, James |
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| Format | Text, Article |
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| Abstract | Exposure of dexamethasone-treated cells of the mT-1 line of F111 rat cells bearing a dexamethasone-inducible polyoma virus middle T (mT) antigen gene to very low concentrations of the protein kinase C-stimulating phorbol ester TPA increased the association of mT antigen with the cellular pp60c-src tyrosine protein kinase, as indicated by an increased phosphorylation of tyrosine residues of mT in mT:pp60c-src complexes precipitated from extracts of the TPA-treated cells by anti-mT antibodies. This TPA (hence probably protein kinase C)-enhanced association of mT with pp60c-src was accompanied by a large increase in the transforming ability of mT as indicated by a much enhanced ability of TPA-treated mT-1 cells producing submaximal levels of mT to proliferate while suspended in semi-solid medium and to form foci on confluent monolayers of normal F111 cells. NRCC NO: 26558. |
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| Publication date | 1986-11-14 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | RAPTIS1986 |
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| NPARC number | 9383011 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 0d9bcac2-45f9-430c-9940-60a5b7a1fabb |
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| Record created | 2009-07-10 |
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| Record modified | 2020-03-17 |
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