| Téléchargement | - Voir le manuscrit accepté : Characterization of L-Digitoxosyl-phenanthroviridin from Streptomyces venezuelae ISP5230 (PDF, 979 Kio)
|
|---|
| DOI | Trouver le DOI : https://doi.org/10.1021/acs.jnatprod.5b00277 |
|---|
| Auteur | Rechercher : Robertson, Andrew W.; Rechercher : Martinez-Farina, Camilo F.; Rechercher : Syvitski, Raymond T.1; Rechercher : Jakeman, David L. |
|---|
| Affiliation | - Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
|
|---|
| Format | Texte, Article |
|---|
| Sujet | aglycone; daunorubicin; digitoxosyl phenanthroviridin; gyrase inhibitor; lysine; unclassified drug; absorption spectroscopy; amino acid metabolism; cancer cell culture; cytotoxicity; fermentation; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; high performance liquid chromatography; human cell; liquid chromatography; mass spectrometry; nuclear Overhauser effect; protein structure; proton nuclear magnetic resonance; Streptomyces venezuelae; tandem mass spectrometry |
|---|
| Résumé | The jadomycin-derived compound l-digitoxosyl-phenanthroviridin was isolated from fermentations of Streptomyces venezuelae ISP5230 grown in nutrient-deficient media with l-lysine as the sole nitrogen source. Structural elucidation was accomplished using a combination of high-resolution MS, LC-MS/MS, and 1D- and 2D-NMR. The compound was evaluated against the National Cancer Institute (NCI) 60 human tumor cell line screen in both the one-dose and five-dose screens, and cytotoxicity was compared to a small library of jadomycin analogues to probe the structure-activity relationship. |
|---|
| Date de publication | 2015-07-23 |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro NPARC | 21277038 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 060c5f22-ee41-4fc5-8909-9e451dc156ac |
|---|
| Enregistrement créé | 2015-11-10 |
|---|
| Enregistrement modifié | 2020-06-04 |
|---|
