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Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine protease inhibitors

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/S0960-894X(02)00765-5
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Name affiliation
  1. National Research Council of Canada. NRC Biotechnology Research Institute
FormatText, Article
Subjectpharmaceutical
Abstract
A series of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one compounds was designed and synthesized as a new class of inhibitors for cysteine proteases cathepsins B, L, K, and S. One compound (5S,6S)-6-(N-benzyloxycarbonyl-l-phenylalanyl) amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one showed excellent cathepsin L and K inhibition activity with IC50 at a low nanomolar range.
Publication date
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  • Bioorganic & Medicinal Chemistry Letters 12, no. 23 (30 October 2002): 3413–3415.
LanguageEnglish
NRC number44866
NPARC number3540101
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Record identifiera7aa3fc2-dd6b-460a-8991-492ef7115e96
Record created2009-03-01
Record modified2020-03-30
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