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Flaxseed lignan secoisolariciresinol diglucoside improves insulin sensitivity through upregulation of GLUT4 expression in diet-induced obese mice

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/j.jff.2015.06.053
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Name affiliation
  1. National Research Council of Canada. Aquatic and Crop Resource Development
FormatText, Article
Subjectdiet-induced obese mice; flaxseed SDG; fasting blood glucose; glucose tolerance; Insulin tolerance; GLUT4
Abstract
The efficacy and mechanism of flaxseed lignan secoisolariciresinol diglucoside (SDG) on glucose hemostasis in obese mice were examined. Male C57BL/6J mice fed on a high-fat diet (60 kcal% fat) for 15 weeks were divided into four groups and treated by oral gavage with 0, 10, 100, or 1000 mg/kg/d of SDG dissolved in water for 6 weeks. Age-matched mice fed with a low-fat diet (10% kcal fat) were used as the normal control. SDG lowered fasting blood glucose, insulin, and free fatty acid levels and improved oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index in mice fed the high-fat diet. Flaxseed SDG also increased GLUT4 expression and tended to increase phosphorylated AKT to total AKT ratio in the muscle tissue. The data demonstrated that flaxseed SDG improved glycaemic control, at least in part, by enhancing insulin signalling and sensitivity in diet-induced obese mice.
Publication date
PublisherElsevier
In
  • Journal of Functional Foods 18: 1–9.
LanguageEnglish
Peer reviewedYes
NRC numberNRC-ACRD-56152
NPARC number21277020
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Record identifier1dc10692-7e03-4b09-9f4e-a2120d0ab722
Record created2015-11-10
Record modified2020-04-22
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