Flaxseed lignan secoisolariciresinol diglucoside improves insulin sensitivity through upregulation of GLUT4 expression in diet-induced obese mice

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1016/j.jff.2015.06.053
Auteur	Rechercher : Wang, Yanwen¹; Rechercher : Fofana, Bourlaye; Rechercher : Roy, Moumita¹; Rechercher : Ghose, Kaushik; Rechercher : Yao, Xing-Hai; Rechercher : Nixon, Marva-Sweeney; Rechercher : Nair, Sandhya; Rechercher : Nyomba, Gregoire B. L.
Affiliation du nom	Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
Format	Texte, Article
Sujet	diet-induced obese mice; flaxseed SDG; fasting blood glucose; glucose tolerance; Insulin tolerance; GLUT4
Résumé	The efficacy and mechanism of flaxseed lignan secoisolariciresinol diglucoside (SDG) on glucose hemostasis in obese mice were examined. Male C57BL/6J mice fed on a high-fat diet (60 kcal% fat) for 15 weeks were divided into four groups and treated by oral gavage with 0, 10, 100, or 1000 mg/kg/d of SDG dissolved in water for 6 weeks. Age-matched mice fed with a low-fat diet (10% kcal fat) were used as the normal control. SDG lowered fasting blood glucose, insulin, and free fatty acid levels and improved oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index in mice fed the high-fat diet. Flaxseed SDG also increased GLUT4 expression and tended to increase phosphorylated AKT to total AKT ratio in the muscle tissue. The data demonstrated that flaxseed SDG improved glycaemic control, at least in part, by enhancing insulin signalling and sensitivity in diet-induced obese mice.
Date de publication	2015-10
Maison d’édition	Elsevier
Dans	Journal of Functional Foods 18 : 1–9.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	NRC-ACRD-56152
Numéro NPARC	21277020
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	1dc10692-7e03-4b09-9f4e-a2120d0ab722
Enregistrement créé	2015-11-10
Enregistrement modifié	2020-04-22

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Date de modification :: 2023-12-07