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Molecular mechanism involved in carotenoid metabolism in post-smolt Atlantic salmon: astaxanthin metabolism during flesh pigmentation and its antioxidant properties

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1007/s10126-021-10055-2
AuthorSearch for: ORCID identifier: https://orcid.org/0000-0003-1414-338X; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
FormatText, Article
SubjectAtlantic salmon; carotenoids; astaxanthin; absorption; antioxidant
Abstract
A better understanding of carotenoid dynamics (transport, absorption, metabolism, and deposition) is essential to develop a better strategy to improve astaxanthin (Ax) retention in muscle of Atlantic salmon. To achieve that, a comparison of post-smolt salmon with (+ Ax) or without (− Ax) dietary Ax supplementation was established based on a transcriptomic approach targeting pyloric, hepatic, and muscular tissues. Results in post-smolts showed that the pyloric caeca transcriptome is more sensitive to dietary Ax supplementation compared to the other tissues. Key genes sensitive to Ax supplementation could be identified, such as cd36 in pylorus, agr2 in liver, or fbp1 in muscle. The most modulated genes in pylorus were related to absorption but also metabolism of Ax. Additionally, genes linked to upstream regulation of the ferroptosis pathway were significantly modulated in liver, evoking the involvement of Ax as an antioxidant in this process. Finally, the muscle seemed to be less impacted by dietary Ax supplementation, except for genes related to actin remodelling and glucose homeostasis. In conclusion, the transcriptome data generated from this study showed that Ax dynamics in Atlantic salmon is characterized by a high metabolism during absorption at pyloric caeca level. In liver, a link with a potential of ferroptosis process appears likely via cellular lipid peroxidation. Our data provide insights into a better understanding of molecular mechanisms involved in dietary Ax supplementation, as well as its beneficial effects in preventing oxidative stress and related inflammation in muscle.
Publication date
PublisherSpringer Nature Switzerland AG
In
  • Marine Biotechnology 23, no. 4 (20 August 2021): 653–670.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

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Record identifier0e57b521-dbeb-4f5d-8dc2-3ce1033e03e1
Record created2021-10-15
Record modified2021-10-15
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