Benzofuran-Derived Cyclic β-Amino Acid Scaffold for Building a Diverse Set of Flavonoid-Like Probes and the Discovery of a Cell Motility Inhibitor

DOI	Trouver le DOI : https://doi.org/10.1021/ol800050g
Auteur	Rechercher : Nandy, Jyoti¹; Rechercher : Rakic, B.; Rechercher : Sarma, B.; Rechercher : Babu, N.; Rechercher : Lefrance, M.; Rechercher : Enright, Gary¹; Rechercher : Leek, Donald¹; Rechercher : Daniel, K.; Rechercher : Sabourin, L.; Rechercher : Arya, Prabhat¹
Affiliation	Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
Format	Texte, Article
Résumé	We report here a practical, enantioselective synthesis of benzofuran-derived, cyclic trans--amino acid scaffold. In two cases, tricyclic derivatives having six- and eight-membered unsaturated lactams were obtained from this versatile scaffold. To explore the biological applications, these compounds were subjected to cell-based assays, using NIH3T3 mouse cells to examine their potency as cell motility inhibitors and identified 18 as a potent cell motility inhibitor (IC50 40 M in chamber cell migration assay).
Date de publication	2008-03-20
Dans	Organic Letters 10, nº 6 (20 mars 2008) : 1143–1146.
Numéro NPARC	12328244
Exporter la notice	Exporter en format RIS
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Identificateur de l’enregistrement	fe29207a-427b-49dd-8f27-4d76e6b137dd
Enregistrement créé	2009-09-10
Enregistrement modifié	2020-04-15