Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamsters

Par Conseil national de recherches du Canada

Téléchargement	Voir le manuscrit accepté : Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamsters (PDF, 617 Kio)
DOI	Trouver le DOI : https://doi.org/10.1016/j.metabol.2004.11.004
Auteur	Rechercher : Wang, Yanwen; Rechercher : Ebine, Naoyuki; Rechercher : Jia, Xiaoming; Rechercher : Jones, Peter J. H.; Rechercher : Fairow, Clint; Rechercher : Jaeger, Ralf
Format	Texte, Article
Sujet	animals; body weight; cholesterol; cricetinae; eating; kinetics; lipids; liver/anatomy & histology; organ size/drug effects
Résumé	The aim of the current study was to examine the effects of very long chain fatty acids (VLCFA) alone at 2 dietary levels, or in combination of VLCFA at the lower level with lecithin (LT) or phytosterols (PS), on lipid profiles and cholesterol biosynthesis in hamsters. Seventy-five male Golden Syrian hamsters, weighing 100 to 120 g, were fed a regular rodent chow for 2 weeks before being randomly assigned into 5 groups of 15 animals each fed semisynthetic diets for 4 weeks. Group 1 was given a control diet that contained 0.25% cholesterol and 5% fat with a polyunsaturated to saturated fatty acids ratio of 0.4. Groups 2 to 5 were fed the control diet and given 25 mg/kg BW per day of VLCFA (Licowax) (VLCFA25), 50 mg/kg BW per day of VLCFA (VLCFA50), 25 mg/kg BW per day of VLCFA + 1000 mg/kg BW per day of LT (VLCFA25/LT), and 25 mg/kg BW per day of VLCFA + 1000 mg/kg BW per day of PS (Cholestatin, VLCFA25/PS), respectively. Results showed that HDL-cholesterol (HDL-C) levels were not changed by VLCFA25, although increased by VLCFA50 (P < .05) relative to control. Total cholesterol (T-C) and non-HDL-C levels were not affected by VLCFA25 and VLCFA50 as compared with control. VLCFA25/LT had higher (P < .02) T-C and HDL-C levels than any other treatments and increased (P < .05) liver weight relative to control. In contrast, VLCFA25/PS reduced T-C (P = .0004) and non-HDL-C (P = .007) without effect on HDL-C levels compared with control. Triglyceride levels were not affected by any treatment. Cholesterol biosynthesis rate was higher (P < .05) in animals fed VLCFA25 and VLCFA50 than those fed control or VLCFA25/LT or VLCFA25/PS. Results suggest that PSs can decrease total and non-HDL-C cholesterol, whereas VLCFA may increase HDL-C in hamsters.
Date de publication	2005-04
Dans	Metabolism 54, nº 4 (avril 2005) : 508–514.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro du CNRC	NRCC 54692
Numéro NPARC	8934195
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Identificateur de l’enregistrement	f63bb8da-c735-47ff-9d69-7a2939e1d8cf
Enregistrement créé	2009-04-23
Enregistrement modifié	2020-04-07

Date de modification :: 2024-05-02