| Téléchargement | - Voir la version finale : Pharmacokinetics and pharmacodynamic effect of a blood-brain barrier-crossing fusion protein therapeutic for Alzheimer’s disease in rat and dog (PDF, 1.2 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1007/s11095-022-03285-z |
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| Auteur | Rechercher : Lessard, Etienne1; Rechercher : Rennie, Kerry1; Rechercher : Haqqani, Arsalan1; Rechercher : Ling, Binbing1; Rechercher : Whitfield, James1; Rechercher : Paradis, Andrea; Rechercher : Araujo, Joseph; Rechercher : Yoganathan, Nathan; Rechercher : Gillard, John; Rechercher : Stanimirovic, Danica1; Rechercher : Chakravarthy, Balu1 |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | Alzheimer's disease; blood-brain barrier-crossing biologics; CNS exposure; pharmacodynamics; pharmacokinetics |
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| Résumé | We have recently demonstrated the brain-delivery of an Amyloid-ß oligomer (Aßo)-binding peptide-therapeutic fused to the BBB-crossing single domain antibody FC5. The bi-functional fusion protein, FC5-mFc-ABP (KG207-M) lowered both CSF and brain Aß levels after systemic dosing in transgenic mouse and rat models of Alzheimer’s disease (AD). For development as a human therapeutic, we have humanized and further engineered the fusion protein named KG207-H. The purpose of the present study was to carry out comparative PK/PD studies of KG207-H in wild type rat and beagle dogs (middle-aged and older) to determine comparability of systemic PK and CSF exposure between rodent species and larger animals with more complex brain structure such as dogs. |
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| Date de publication | 2022-06-15 |
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| Maison d’édition | Springer Nature |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | 3285 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | f46400b2-446c-49ba-a6c4-94eb4f15a6c2 |
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| Enregistrement créé | 2024-02-27 |
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| Enregistrement modifié | 2024-02-27 |
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