| DOI | Trouver le DOI : https://doi.org/10.1016/j.jasms.2005.01.025 |
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| Auteur | Rechercher : Forbes, Matthew W.1; Rechercher : Volmer, Dietrich A.1; Rechercher : Francis, Gregory J.; Rechercher : Bohme, Diethard K. |
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| Affiliation | - Conseil national de recherches du Canada. Institut des biosciences marines du CNRC
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| Format | Texte, Article |
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| Sujet | antibiotics; methods; mass spectrometry |
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| Résumé | The gas phase stabilities of Group I metal complexes of the polyether ionophore antibiotics lasalocid and monensin were investigated by collision induced dissociation mass spectrometry. Electrospray ionization was used with a triple quadrupole mass spectrometer for the determination of threshold dissociation energies upon application of increasing collision energies. Various data analysis techniques for the determination of dissociation energies are discussed to assess the most suitable method for determining the stabilities of the ionophore-metal complexes studied here. In all cases only the relative stabilities of different complexes may be obtained by the method presented in this study, which does not assess absolute gas phase dissociation energies. Correction factors have been applied, however, to account for the energy conversion during collisions of different metal complexes and the varying degrees of freedom of different sized ligands, allowing for the comparison of the stabilities of different ionophores with like-metals. The measured threshold dissociation energies were compared with respect to the ionic radius of the metal cation, revealing a maximum stability for the K+ complexes of both lasalocid and monensin. A striking decrease in the stabilities of the Rb+ and Cs+ complexes was observed and is believed to be related to a decreasing degree of coordination that the ionophores can accomplish with the larger metals. |
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| Date de publication | 2005-05 |
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| Conditions d’utilisation | - Copyright © 2005 American Society for Mass Spectrometry
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | 1662 |
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| Numéro NPARC | 3538047 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | f2afd150-32f5-4c3e-b50c-5c45e1ea47a1 |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-04-07 |
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