Increases in rat liver cyclic AMP concentrations prior to the initiation of DNA synthesis following partial hepatectomy or hormone infusion

DOI	Trouver le DOI : https://doi.org/10.1016/0006-291X(72)90596-7
Auteur	Rechercher : MacManus, J. P.¹; Rechercher : Franks, D. J.¹; Rechercher : Youdale, T.¹; Rechercher : Braceland, B. M.¹
Affiliation	Conseil national de recherches Canada. Institut des sciences biologiques du CNRC
Format	Texte, Article
Résumé	In rat liver following partial hepatectomy an unprecedented biphasic increase in cyclic AMP concentration was observed. After a lag period of 112hr, the cyclic AMP content rose to a peak at 212hr. The cyclic AMP level fell to normal at 8 hr, and then rose again to a second peak at 12 hr. DNA synthesis started at 18 hr, by which time the cyclic AMP level was approaching control values. A biphasic increase in cyclic AMP concentration was also observed to precede the initiation of DNA synthesis in intact liver following the infusion of a mixture of tri-iodothyronine, amino acids, glucagon and heparin. The relationship between these biphasic changes in cyclic AMP levels and the initiation of DNA synthesis in liver is discussed.
Date de publication	1972-12-04
Maison d’édition	Elsevier
Dans	Biochemical and Biophysical Research Communications 49, nº 5 : 1201–1207.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	MACMANUS1972B
Numéro NPARC	9380214
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	f2318539-5641-46e6-b70f-bdb609f7768d
Enregistrement créé	2009-07-10
Enregistrement modifié	2020-03-13

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Date de modification :: 2026-10-12