| DOI | Trouver le DOI : https://doi.org/10.3945/ajcn.117.154708 |
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| Auteur | Rechercher : Léveillé, Pauline; Rechercher : Chouinard-Watkins, Raphaël; Rechercher : Windust, Anthony1; Rechercher : Lawrence, Peter; Rechercher : Cunnane, Stephen C; Rechercher : Brenna, J Thomas; Rechercher : Plourde, Mélanie |
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| Affiliation | - Conseil national de recherches du Canada. Science des mesures et étalons
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| Format | Texte, Article |
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| Sujet | aging; arachidonic acid; docosahexaenoic acid; eicosapentaenoic acid; metabolism |
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| Résumé | Background: Plasma eicosapentaenoic acid (EPA) and arachidonic acid (AA) concentrations increase with age. Objective: The aim of this study was to evaluate EPA and AA metabolism in young and old men by using uniformly labeled carbon-13 (13C) fatty acids. Design: Six young (∼25 y old) and 6 old (∼75 y old) healthy men were recruited. Each participant consumed a single oral dose of 35 mg 13C-EPA and its metabolism was followed in the course of 14 d in the plasma and 28 d in the breath. After the washout period of ≥28 d, the same participants consumed a single oral dose of 50 mg 13C-AA and its metabolism was followed for 28 d in plasma and breath. Results: There was a time × age interaction for 13C-EPA (Ptime × age = 0.008), and the shape of the postprandial curves was different between young and old men. The 13C-EPA plasma half-life was ∼2 d for both young and old men (P = 0.485). The percentage dose recovered of 13C-EPA per hour as 13CO2 and the cumulative β-oxidation of 13C-EPA did not differ between young and old men. At 7 d, however, old men had a >2.2-fold higher plasma 13C-DHA concentration synthesized from 13C-EPA compared with young men (Page = 0.03). 13C-AA metabolism was not different between young and old men. The 13C-AA plasma half-life was ∼4.4 d in both young and old participants (P = 0.589). Conclusions: The metabolism of 13C-AA was not modified by age, whereas 13C-EPA metabolism was slightly but significantly different in old compared with young men. The higher plasma 13C-DHA seen in old men may be a result of slower plasma DHA clearance with age. This trial was registered at clinicaltrials.gov as NCT02957188. |
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| Date de publication | 2017-06-28 |
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| Maison d’édition | Oxford University Press |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23003198 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | ed9fee62-e6af-4661-bef0-067a8283d392 |
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| Enregistrement créé | 2018-05-07 |
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| Enregistrement modifié | 2020-03-16 |
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