| Lien | http://www.rsc.org/images/LOC/2011/PDFs/Papers/199_0885.pdf |
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| Auteur | Rechercher : Singh, Reshma; Rechercher : Jemere, Abebaw B.1; Rechercher : Wang, Zhen; Rechercher : Brett, Michael1; Rechercher : Harrison, D. Jed1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut national de nanotechnologie
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| Format | Texte, Article |
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| Conférence | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, October 2-6, 2011, Seattle, WA, USA |
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| Sujet | Background signals; Desorption/ionization; GLAD; Laser desorption/ionization; Laser desorption/ionization mass spectrometries; Matrix assisted laser desorption/ionization; Nanoporous structures; Porous thin films; Mass spectrometry; Peptides; Porous silicon; Thin films; Desorption |
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| Résumé | The performance of porous silicon and cobalt glancing angle deposited (GLAD) thin films for matrix-free laser desorption/ionization-MS analysis of carbohydrates, peptides and drugs with molecular weights < 2,500 Dalton is presented. The performance of these films for selected peptides and small drugs detection is similar to the best reported for desorption/ionization on electrochemically etched porous silicon with detection limits in the femtomole to sub-femtomole range, and was superior to matrix-assisted laser desorption/ionization (MALDI)-MS in terms of background signal and spot-to-spot reproducibility. Copyright © (2011) by the Chemical and Biological Microsystems Society. |
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| Date de publication | 2011 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21271975 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | e9f4d402-a341-4747-81f5-0920ba013009 |
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| Enregistrement créé | 2014-05-14 |
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| Enregistrement modifié | 2020-04-21 |
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