A Haemophilus influenzae strain associated with Fisher syndrome expresses a novel disialylated ganglioside mimic

Par Conseil national de recherches du Canada

Auteur	Rechercher : Houliston, R.; Rechercher : Koga, M.; Rechercher : Li, J.; Rechercher : Jarrell, Harold; Rechercher : Richards, J.; Rechercher : Vitiazeva, V.; Rechercher : Schweda, E.; Rechercher : Yuki, N.; Rechercher : Gilbert, M.
Format	Texte, Article
Sujet	acid; acid residues; adult; antibody; backbone; Canada; carbohydrate sequence; ganglioside; Haemophilus; Haemophilus influenzae; Lipooligosaccharide; magnetic resonance spectroscopy; male; mass spectrometry; metabolism; microbiology; miller fisher syndrome; molecular mimicry; molecular sequence data; physiology; residues; serum; sialic; sialic-acid; strain; surface; syndrome; target; trisaccharide
Résumé	The non-typeable Haemophilus influenzae strain DH1 was isolated from a 25 year old male patient with Fisher syndrome, a postinfectious autoimmune condition characterized by the presence of anti-GQ1b IgG antibodies that target and initiate damage to peripheral nerves. DH1 was found to display an alphaNeuAc(2-8)alphaNeuAc(2-3)betaGal branch bound to the tetraheptosyl backbone core of its lipooligosaccharide (LOS). The novel sialylation pattern was found to be dependent on the activity of a bifunctional sialyltransferase, Lic3B, which catalyzes the addition of both the terminal and subterminal sialic acid residues. Patient serum IgGs bind to DH1 LOS, and the reactivity is significantly influenced by the presence of sialylated glycoforms. The display by DH1, of a surface glycan that mimics the terminal trisaccharide portion of disialosyl-containing gangliosides, provides strong evidence for its involvement in the development of Fisher syndrome
Date de publication	2007-07-10
Dans	Biochemistry 46, nº 27 (10 juillet 2007) : 8164–8171.
Langue	anglais
Numéro du CNRC	HOULISTON2007
Numéro NPARC	9387155
Exporter la notice	Exporter en format RIS
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Identificateur de l’enregistrement	e8ac8f4a-4a42-45ad-a528-92ba9d338cae
Enregistrement créé	2009-07-10
Enregistrement modifié	2020-05-10

Date de modification :: 2024-07-09