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Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine

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DOITrouver le DOI : https://doi.org/10.1016/j.envpol.2022.119521
AuteurRechercher : Identifiant ORCID : https://orcid.org/0000-0002-1340-5336; Rechercher : Identifiant ORCID : https://orcid.org/0000-0001-7509-5970; Rechercher : Identifiant ORCID : https://orcid.org/0000-0001-6794-1727; Rechercher : ; Rechercher : Identifiant ORCID : https://orcid.org/0000-0001-6211-2815; Rechercher : ; Rechercher : ; Rechercher : Identifiant ORCID : https://orcid.org/0000-0003-3562-879X; Rechercher : ; Rechercher : Identifiant ORCID : https://orcid.org/0000-0001-9092-4861; Rechercher : ; Rechercher : 1Identifiant ORCID : https://orcid.org/0000-0003-0626-6646; Rechercher : ; Rechercher : ; Rechercher : Identifiant ORCID : https://orcid.org/0000-0002-4288-7995
Affiliation
  1. Conseil national de recherches Canada. Centre de recherche en métrologie
FormatTexte, Article
Sujetaerosol; aircraft engine exhaust; bronchial epithelial cell culture; cellular response; non-volatile particulate matter
Résumé
Health effects of particulate matter (PM) from aircraft engines have not been adequately studied since controlled laboratory studies reflecting realistic conditions regarding aerosols, target tissue, particle exposure and deposited particle dose are logistically challenging. Due to the important contributions of aircraft engine emissions to air pollution, we employed a unique experimental setup to deposit exhaust particles directly from an aircraft engine onto reconstituted human bronchial epithelia (HBE) at air-liquid interface under conditions similar to in vivo airways to mimic realistic human exposure. The toxicity of non-volatile PM (nvPM) from a CFM56-7B26 aircraft engine was evaluated under realistic engine conditions by sampling and exposing HBE derived from donors of normal and compromised health status to exhaust for 1 h followed by biomarker analysis 24 h post exposure. Particle deposition varied depending on the engine thrust levels with 85% thrust producing the highest nvPM mass and number emissions with estimated surface deposition of 3.17 × 10⁹ particles cm⁻² or 337.1 ng cm⁻². Transient increase in cytotoxicity was observed after exposure to nvPM in epithelia derived from a normal donor as well as a decrease in the secretion of interleukin 6 and monocyte chemotactic protein 1. Non-replicated multiple exposures of epithelia derived from a normal donor to nvPM primarily led to a pro-inflammatory response, while both cytotoxicity and oxidative stress induction remained unaffected. This raises concerns for the long-term implications of aircraft nvPM for human pulmonary health, especially in occupational settings.
Date de publication
Maison d’éditionElsevier
Déclaration de droit d’auteur
  • © 2022 The Authors
Licence
Dans
  • Environmental Pollution 307, nº C, 119521 (24 mai 2022).
Langueanglais
Publications évaluées par des pairsOui
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Identificateur de l’enregistremente5990e11-625e-4abb-9718-fc398fd60afa
Enregistrement créé2023-07-26
Enregistrement modifié2026-04-17

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