DOI | Trouver le DOI : https://doi.org/10.1002/elps.200500832 |
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Auteur | Rechercher : Djang'eing'a Marni, Roland; Rechercher : Groom, Carl1; Rechercher : Doucet, François R.1; Rechercher : Al-Hawari, Jalal1; Rechercher : Bitar, Yaser; Rechercher : Holzgrabe, Ulrike; Rechercher : Gotti, Roberto; Rechercher : Schappler, Julie; Rechercher : Rudaz, Serge; Rechercher : Veuthey, Jean-Luc; Rechercher : Mol, Roelof; Rechercher : Somsen, Govert W.; Rechercher : de Jong, Gerhardus J; Rechercher : Thanh Ha, Pham Thi; Rechercher : Zhang, Jie; Rechercher : Van Schepdael, Ann; Rechercher : Hoogmartens, Jos; Rechercher : Briône, Willy; Rechercher : Ceccato, Attilio; Rechercher : Boulanger, Bruno; Rechercher : Mangelings, Debby; Rechercher : Vander Heyden, Yvan; Rechercher : Van Ael, Willy; Rechercher : Jimidar, Ilias; Rechercher : Pedrini, Matteo; Rechercher : Servais, Anne-Catherine; Rechercher : Fillet, Marianne; Rechercher : Crommen, Jacques; Rechercher : Rozet, Eric; Rechercher : Hubert, Philippe |
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Affiliation | - Conseil national de recherches du Canada. Institut de recherche en biotechnologie du CNRC
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Format | Texte, Article |
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Sujet | environmental; interlaboratory study; nonaqueous capillary electrophoresis; reproducibility; R-Timolol; uncertainty estimation |
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Résumé | Analyses of statistical variance were applied to evaluate the precision and practicality of a CD-based NACE assay for R-timolol after enantiomeric separation of R- and S-timolol. Data were collected in an interlaboratory study by 11 participating laboratories located in Europe and North America. General qualitative method performance was examined using suitability descriptors (i.e. resolution, selectivity, migration times and S/N), while precision was determined by quantification of variances in the determination of R-timolol at four different impurity levels in S-timolol maleate samples. The interlaboratory trials were designed in accordance with the ISO guideline 5725-2. This allowed estimating for each sample, the different variances, i.e. between-laboratory (s2(Laboratories)), between-day (s2(Days)) and between-replicate (s2(Replicates)). The variances of repeatability (s2r) and reproducibility (s2R) were then calculated. The estimated uncertainty, derived from the precision estimates, seems to be concentration-dependent above a given threshold. This example of R-timolol illustrates how a laboratory can evaluate uncertainty in general. |
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Date de publication | 2006-05-22 |
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Dans | |
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Langue | anglais |
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Numéro du CNRC | 47266 |
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Numéro NPARC | 3539328 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | dfce42d8-8213-457b-a516-eb500b106ebd |
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Enregistrement créé | 2009-03-01 |
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Enregistrement modifié | 2020-04-22 |
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