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Stability of pressure-extruded liposomes made from archaeobacterial ether lipids

DOITrouver le DOI : https://doi.org/10.1007/BF00902745
AuteurRechercher : 1; Rechercher : 1; Rechercher : ; Rechercher : 1
Affiliation
  1. Conseil national de recherches Canada. Institut des sciences biologiques du CNRC
FormatTexte, Article
Résumé
Ether lipids were obtained from a wide range of archaeobacteria grown at extremes of pH, temperature, and salt concentration. With the exception ofSulfolobus acidocaldarius, unilamellar and/or multilamellar liposomes could be prepared from emulsions of total polar lipid extracts by pressure extrusion through filters of various pore sizes. Dynamic light scattering, and electron microscopy revealed homogeneous liposome populations with sizes varying from 40 to 230 nm, depending on both the lipid source and the pore size of the filters. Leakage rates of entrapped fluorescent or radioactive compounds established that those archaeobacterial liposomes that contained tetraether lipids were the most stable to high temperatures, alkaline pH, and serum proteins. Most ether liposomes were stable to phospholipase A2, phospholipase B and pancreatic lipase. These properties of archaeobacterial liposomes make them attractive for applications in biotechnology.
Date de publication
Dans
  • Applied Microbiology and Biotechnology 42, nº 2-3 (1994) : 375–384.
Langueanglais
Numéro du CNRCCHOQUET1994B
NRCC 37391
Numéro NPARC9382920
Exporter la noticeExporter en format RIS
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Identificateur de l’enregistrementdd983f9f-b5f1-4ad1-92d1-8b76f1976c82
Enregistrement créé2009-07-10
Enregistrement modifié2020-04-27

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