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Structural and immunochemical characterization of the type VIII group B Streptococcus capsular polysaccharide

AuteurRechercher : ; Rechercher : ; Rechercher : ; Rechercher : ; Rechercher : ; Rechercher : ; Rechercher :
FormatTexte, Article
Sujet13C-NMR; 1H-NMR; acids; antigens; antigens, bacterial; bacterial; bacterial capsules; Canada; capsular polysaccharide; capsule; carbohydrate sequence; chemistry; d-glucose; group B Streptococcus; high-resolution; immunochemical characterization; immunology; magnetic resonance spectroscopy; Meningitis; molar; molecular sequence data; Neuraminidase; NMR spectroscopy; nuclear magnetic resonance; oxidation-reduction; polysaccharides; repeating unit; resolution; resonance; sialic acids; strains; Streptococcus; Streptococcus agalactiae; structural; structure; support, U.S. Gov't, P.H.S.; unit
Résumé
The type VIII capsular polysaccharide has been isolated and purified from a newly described strain of group B Streptococcus which is a leading cause of sepsis and neonatal meningitis in Japan. The polysaccharide contains D-glucose, D-galactose, L-rhamnose, and sialic acid in the molar ratio 1:1:1:1. By means of high resolution 1H nuclear magnetic resonance (1H NMR), 13C NMR, and homo- and heterocorrelated NMR, the repeating unit structure of the type VIII polysaccharide was delineated as the following, [formula: see text] Enzymatic studies established this polysaccharide as the first from which sialic acid, linked to a branched beta-D-galactopyranosyl residue, is known to be removed by bacterial neuraminidase
Date de publication
Maison d’éditionAmerican Society for Biochemistry and Molecular Biology
Dans
  • The Journal of Biological Chemistry 271, nº 15 : 8786–8790.
Langueanglais
Publications évaluées par des pairsOui
Numéro du CNRCKOGAN1996
Numéro NPARC9364359
Exporter la noticeExporter en format RIS
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Identificateur de l’enregistrementd70dd315-1daf-4e1a-ae56-d58768d6b8ba
Enregistrement créé2009-07-10
Enregistrement modifié2020-03-20

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