| Téléchargement | - Voir la version finale : Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI (PDF, 4.5 Mio)
- Voir les données supplémentaires : Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI (PDF, 258 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1038/s41598-022-07000-1 |
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| Auteur | Rechercher : Zabel, W. Jeffrey; Rechercher : Allam, Nader; Rechercher : Foltz, Warren D.; Rechercher : Flueraru, Costel1; Rechercher : Taylor, Edward; Rechercher : Vitkin, I. Alex |
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| Affiliation | - Conseil national de recherches du Canada. Électronique et photonique avancées
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| Bailleur de fonds | Rechercher : Princess Margaret Cancer Foundation; Rechercher : Terry Fox Foundation; Rechercher : Natural Sciences and Engineering Research Council of Canada; Rechercher : Temerty Faculty of Medicine, University of Toronto; Rechercher : Canadian Institutes of Health Research |
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| Format | Texte, Article |
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| Résumé | Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is emerging as a valuable tool for non-invasive volumetric monitoring of the tumor vascular status and its therapeutic response. However, clinical utility of DCE-MRI is challenged by uncertainty in its ability to quantify the tumor microvasculature (μm scale) given its relatively poor spatial resolution (mm scale at best). To address this challenge, we directly compared DCE-MRI parameter maps with co-registered micron-scale-resolution speckle variance optical coherence tomography (svOCT) microvascular images in a window chamber tumor mouse model. Both semi and fully quantitative (Toft’s model) DCE-MRI metrics were tested for correlation with microvascular svOCT biomarkers. svOCT’s derived vascular volume fraction (VVF) and the mean distance to nearest vessel (DNV) metrics were correlated with DCE-MRI vascular biomarkers such as time to peak contrast enhancement (r=−0.81 and 0.83 respectively, P<0.0001 for both), the area under the gadolinium-time concentration curve (r=0.50 and −0.48 respectively, P<0.0001 for both) and ktrans (r=0.64 and −0.61 respectively, P<0.0001 for both). Several other correlated micro–macro vascular metric pairs were also noted. The microvascular insights afforded by svOCT may help improve the clinical utility of DCE-MRI for tissue functional status assessment and therapeutic response monitoring applications. |
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| Date de publication | 2022-02-24 |
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| Maison d’édition | Springer Nature Limited |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | d43ff0c2-97bb-4453-ab02-286e572249c9 |
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| Enregistrement créé | 2022-03-16 |
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| Enregistrement modifié | 2022-03-16 |
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