Conformation of the peptide hormone somatostatin in aqueous solution and organic solvents

DOI	Trouver le DOI : https://doi.org/10.1016/0924-2031(92)85010-X
Auteur	Rechercher : Jackson, Michael¹; Rechercher : Mantsch, Henry H.¹
Affiliation	Conseil national de recherches Canada. Institut du biodiagnostic du CNRC
Format	Texte, Article
Sujet	Infrared spectrometry; Conformational analysis; Peptide hormones; Somatostatin
Résumé	Fourier transform infrared spectroscopy was applied to the conformational analysis of somatostatin in H₂O, ²H₂O, dimethyl sulphoxide (DMSO)-²H₂O and DMSO. The results suggest that in these solvents the peptide adopts a similar structure. In agreement with circular dichroism (CD) spectroscopic data, evidence for turn structures was found; however, there was no evidence for the intramolecular β-sheet secondary structures proposed on the basis of Raman and CD spectroscopic results. Rather, the amide C=O and NH groups not involved in turns appear to be either hydrogen bonded to the solvent or free.
Date de publication	1992-07-07
Dans	Vibrational Spectroscopy 3, nº 4 : 323–326.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	NRC-IBD-45
Numéro NPARC	9741988
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	cf507813-bb51-481c-bac1-c3ac904061b4
Enregistrement créé	2009-07-17
Enregistrement modifié	2020-04-24