| DOI | Trouver le DOI : https://doi.org/10.1002/rcm.2650 |
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| Auteur | Rechercher : Sleno, Lekha1; Rechercher : Daneshfar, Rambod1; Rechercher : Eckert, Gunter P.; Rechercher : Muller, Walter E.; Rechercher : Volmer, Dietrich A.1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut des biosciences marines du CNRC
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| Format | Texte, Article |
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| Sujet | methods; mass spectrometry; Hypericum perforatum; St. John's wort |
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| Résumé | Active phloroglucinol constituents of Hypericum perforatum (St. John's wort) extracts, hyperforin and adhyperforin, have been studied following ion activation using tandem mass spectrometry (MS/MS) and complemented by accurate mass measurements. These two compounds were readily analyzed as protonated and deprotonated molecules with electrospray ionization. MS/MS and MS3 data from a quadrupole-linear ion trap tandem mass spectrometer were employed to elucidate fragmentation pathways. Fourier transform ion cyclotron resonance measurements afforded excellent mass accuracies for the confirmation of elemental formulae of product ions formed via infrared multiphoton dissociation and sustained off-resonance irradiation collision-induced dissociation. Fragmentation schemes have been devised for the dissociation of hyperforin and adhyperforin in negative and positive ion modes. This information is expected to be especially valuable for the characterization of related compounds, such as degradation products, metabolites and novel synthetic analogs of hyperforin. |
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| Date de publication | 2006-09-30 |
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| Conditions d’utilisation | - Copyright © 2006 John Wiley & Sons, Ltd.
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | NRC-ACRD-55906 |
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| Numéro du CNRC | 1621 |
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| Numéro NPARC | 3538410 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | c36773eb-543d-4b8e-9fb7-96381d98ed5e |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-04-22 |
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