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Neuroregenerative strategies in the brain: emerging significance of bonemorphogenetic protein 7 (BMP7)

Par Conseil national de recherches du Canada

DOITrouver le DOI : https://doi.org/10.1139/O08-116
AuteurRechercher : 1; Rechercher : 1; Rechercher : 2; Rechercher : ; Rechercher : 1; Rechercher : 1; Rechercher : 1; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
  2. Conseil national de recherches du Canada. Institut des matériaux industriels du CNRC
FormatTexte, Article
Sujetbone morphogenetic protein 7; brain; brain injuries; Canada; cell differentiation; cell survival; cell transplantation; cytokines; disease; drug therapy; metabolism; model; nerve regeneration; neurogenesis; neuroprotective agents; pathology; physiology; potential; program; protein; role; stroke; therapeutic use; therapy; tissue engineering
Résumé
Every year thousands of people suffer from brain injuries and stroke, anddevelop motor, sensory, and cognitive problems as a result of neuronal loss in thebrain. Unfortunately, the damaged brain has a limited ability to enact repair andcurrent modes of treatment are not sufficient to offset the damage. An extensivelist of growth factors, neurotrophic factors, cytokines, and drugs has been exploredas potential therapies. However, only a limited number of them may actually have thepotential to effectively offset the brain injury or stroke-related problems. One ofthe treatments considered for future brain repair is bone morphogenetic protein 7(BMP7), a factor currently used in patients to treat non-neurological diseases. The clinical application of BMP7 is based on its neuroprotective role in stroke animal models. This paper reviews the current approac hes considered for brain repair and discusses the novel convergent strategies by which BMP7 potentially can induce neuroregeneration
Date de publication
Dans
  • Biochemistry and Cell Biology 86, nº 5 (octobre 2008) : 361–369.
Langueanglais
Numéro du CNRCBANIYAGHOUB2008
Numéro NPARC9375333
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Identificateur de l’enregistrementc2fe6c23-ec49-4ffa-b635-61d6ab480ac3
Enregistrement créé2009-07-10
Enregistrement modifié2020-04-15
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