| Téléchargement | - Voir le manuscrit accepté : Association of anti-GT1a antibodies with an outbreak of Guillain-Barré syndrome and analysis of ganglioside mimicry in an associated Campylobacter jejuni strain (PDF, 667 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1371/journal.pone.0131730 |
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| Auteur | Rechercher : Zhang, Maojun; Rechercher : Gilbert, Michel1; Rechercher : Yuki, Nobuhiro; Rechercher : Cao, Fangfang; Rechercher : Li, Jianjun1; Rechercher : Liu, Hongying; Rechercher : Li, Qun; Rechercher : Meng, Fanliang; Rechercher : Zhang, Jianzhong |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | anti-ganglioside antibody; phylogenetic analysis; antigenic drift; ganglioside antibody; ganglioside GD 1b; ganglioside GD3; ganglioside GM1; ganglioside GM2; ganglioside GQ 1b; ganglioside GT 1a; glycosyltransferase; immunoglobulin G antibody; immunoglobulin M antibody; lipooligosaccharide; antibody blood level; bacterial genome; bacterial strain; cgtA gene; cgtB gene; cst II gene; diarrhea; DNA sequence; gastroenteritis; molecular mimicry; phylogenetic tree; phylogeny; single nucleotide polymorphism |
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| Résumé | An outbreak of Guillain-Barré syndrome (GBS), subsequent to Campylobacter jejuni enteritis, occurred in China in 2007. Serum anti-ganglioside antibodies were measured in GBS patients and controls. Genome sequencing was used to determine the phylogenetic relationship among three C. jejuni strains from a patient with GBS (ICDCCJ07001), a patient with gastroenteritis (ICDCCJ07002) and a healthy carrier (ICDCCJ07004), which were all associated with the outbreak. The ganglioside-like structures of the lipo-oligosaccharides of these strains were determined by mass spectrometry. Seventeen (53%) of the GBS patients had anti-GT1a IgG antibodies. GT1a mimicry was found in the lipo-oligosaccharides of strain ICDCCJ07002 and ICDCCJ07004; but a combination of GM3/GD3 mimics was observed in ICDCCJ07001, although this patient had anti-GT1a IgG antibodies. A single-base deletion in a glycosyltransferase gene caused the absence of GT1a mimicry in ICDCCJ07001. The phylogenetic tree showed that ICDCCJ07002 and ICDCCJ07004 were genetically closer to each other than to ICDCCJ07001. C. jejuni, bearing a GT1a-like lipo-oligosaccharide, might have caused the GBS outbreak and the loss of GT1a mimicry may have helped ICDCCJ07001 to survive in the host. |
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| Date de publication | 2015-07-21 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | NRC-HHT-53231 |
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| Numéro NPARC | 21275343 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | c29b6749-3a3c-4e6d-85b8-81bc3b0df95c |
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| Enregistrement créé | 2015-06-15 |
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| Enregistrement modifié | 2020-06-04 |
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