| Auteur | Rechercher : Bateman, K.; Rechercher : Thibault, P.; Rechercher : Yang, K.; Rechercher : White, R.; Rechercher : Vining, L. |
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| Format | Texte, Article |
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| Sujet | streptogramin; antibiotic resistance; enzyme; substrate specificity; Streptomyces lividans |
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| Résumé | LC–MS and LC–MS/MS analyses indicated that an enzyme responsible for inactivating the antibiotic etamycin is specific for streptogramins and acts on both type B‐I and B‐II streptogramin subgroups. No enzymatic activity was detected for other cyclodepsipeptides such as surfactins and viscosin. It was demonstrated using analogs of etamycin that the picolinyl moiety is essential to obtain enzyme‐generated ring‐opened compounds. Because the picolinyl moiety is also essential for the biological activity of streptogramins, it is proposed that this residue is a distinctive topographic feature in the binding of this group of antibiotics to enzyme active sites. |
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| Date de publication | 1997-11 |
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| Maison d’édition | Wiley |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | BATEMAN1997A |
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| Numéro NPARC | 9376073 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | bf3f15d5-718b-4ef3-9c1f-c572f41d81c7 |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-03-20 |
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