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| DOI | Trouver le DOI : https://doi.org/10.1016/j.virol.2022.01.012 |
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| Auteur | Rechercher : Matsuyama-Kato, Ayumi; Rechercher : Iseki, Hiroshi; Rechercher : Boodhoo, Nitish; Rechercher : Bavananthasivam, Jegarubee1; Rechercher : Alqazlan, Nadiyah; Rechercher : Abdul-Careem, Mohamed Faizal; Rechercher : Plattner, Brandon L.; Rechercher : Behboudi, Shahriar; Rechercher : Sharif, ShayanIdentifiant ORCID : https://orcid.org/0000-0002-3158-012X |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Bailleur de fonds | Rechercher : Pirbright Institute; Rechercher : Natural Sciences and Engineering Research Council of Canada; Rechercher : Ontario Ministry of Agriculture, Food and Rural Affairs; Rechercher : UK Research and Innovation; Rechercher : Biotechnology and Biological Sciences Research Council |
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| Format | Texte, Article |
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| Sujet | Marek’s disease virus; vaccine; aerosol infection; chicken; γδ T cell; cytokine; cytotoxicity |
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| Résumé | Marek’s disease (MD) vaccines reduce the incidence of MD but cannot control virus shedding. To develop new vaccines, it is essential to elucidate mechanisms of immunity to Marek’s disease virus (MDV) infection. In this regard, gamma delta (γδ) T cells may play a significant role in prevention of viral spread and tumor surveillance. Here we demonstrated that MDV vaccination induced interferon (IFN)-γ⁺CD8α⁺ γδ T cells and transforming growth factor (TGF)-β⁺ γδ T cells in lungs. γδ T cells from MDV-infected chickens exhibited cytotoxic activity. Importantly, γδ T cells from the vaccinated/challenged group exhibited maximum cytotoxic activity following ex vivo stimulation. These results suggest that MDV vaccines activate effector γδ T cells which may be involved in the development of protective immune responses against MD. Further, it was demonstrated that MDV infection increases the frequency of a subpopulation of γδ T cells expressing membrane-bound TGF-β in MDV-infected birds. |
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| Date de publication | 2022-01-25 |
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| Maison d’édition | Elsevier |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | S0042682222000198 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | bf17df90-fb7e-4ef5-97d9-6bb95901427c |
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| Enregistrement créé | 2024-02-19 |
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| Enregistrement modifié | 2024-02-19 |
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