Constituents of the Vietnamese medicinal plant Orthosiphon stamineus.

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1248/cpb.48.1711
Auteur	Rechercher : Tezuka, Yasuhiro; Rechercher : Stampoulis, Pavlos; Rechercher : Banskota, Arjun H.; Rechercher : Awale, Suresh; Rechercher : Tran, Kim Qui; Rechercher : Saiki, Ikuo; Rechercher : Kadota, Shigetoshi
Format	Texte, Article
Sujet	Orthosiphon stamineus; staminane-type diterpene; Vietnamese medicinal plant; isopimarane-type diterpene; cytotoxicity; colon 26-L5 carcinoma
Résumé	From the MeOH extract of the aerial part of Vietnamese Orthosiphon stamineus, five new isopimarane-type diterpenes [orthosiphols F-J (1-5)] and two new diterpenes [staminols A (6) and B (7)] with a novel carbon-framework, to which we proposed the name "staminane", and three new highly-oxygenated staminane-type diterpenes [staminolactones A (8) and B (9) and norstaminol A (10)] were isolated. Moreover, staminolactone A (8) is 8, 14-secostaminane-type and staminolactone B (9) is 13, 14-secostaminane-type, while norstaminol A (10) is 14-norstaminen-type. Together with these new diterpenes, sixteen known compounds were also isolated and identified to be : 7, 3', 4'-tri-O-methylluteolin (11), eupatorin (12), sinensetin (13), 5-hydroxy-6, 7, 3'4'-tetramethoxyflavone (14), salvigenin (15), ladanein (16), tetramethylscutellarein (17), 6-hydroxy-5, 7, 4'-trimethoxyflavone (18), vomifoliol (19), aurantiamide acetate (20), rosmarinic acid (21), caffeic acid (22), oleanolic acid (23), ursolic acid (24), betulinic acid (25), and β-sitosterol (26). All the isolated compounds were tested for their cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, and the new diterpenes, except for 4, and flavonoids (11, 12, 16, 18) showed cytotoxicity with an ED^50 value between 10 and 90 μg/ml.
Date de publication	2000-11-01
Dans	Chemical and Pharmaceutical Bulletin 48, nº 11 (1 novembre 2000) : 1711–1719.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	21275296
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Identificateur de l’enregistrement	b49c52a9-7f75-4d66-abb1-c7482862760d
Enregistrement créé	2015-06-02
Enregistrement modifié	2020-03-26

Date de modification :: 2026-01-15