| DOI | Trouver le DOI : https://doi.org/10.1016/0006-291X(80)90849-9 |
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| Auteur | Rechercher : Boynton, A.; Rechercher : Whitfield, James; Rechercher : Macmanus, J. |
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| Format | Texte, Article |
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| Résumé | Incubation in low (0.02 mM)-calcium medium prevented T51B rat liver cells from initiating DNA synthesis. Raising the calcium concentration in the medium from 0.02 to 1.25 mM caused these arrested cells to initiate DNA synthesis 1–2 hours later. The possibility of this rapid DNA-synthetic response to calcium addition being mediated through Ca-calmodulin complexes was suggested by the following observations: It was blocked by the putative Ca-calmodulin blockers chlorpromazine and trifluoperazine; the trifluoperazine-inhibited cells were stimulated by purified rat calmodulin; and purified rat calmodulin itself (10−7 to 10−6 moles/l) mimicked calcium action, unless the already low ionic calcium concentration in the calcium-deficient medium was reduced further by adding the specific calcium chelator EGTA. |
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| Date de publication | 1980-07-31 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | BOYNTON1980C |
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| Numéro NPARC | 9373851 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | afa409ea-5477-4c04-b94e-15fc65745744 |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-03-13 |
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