Longitudinal in-vivo quantification of tumour microvascular heterogeneity by optical coherence angiography in pre-clinical radiation therapy

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DOI	Trouver le DOI : https://doi.org/10.1038/s41598-022-09625-8
Auteur	Rechercher : Allam, Nader; Rechercher : Jeffrey Zabel, W.; Rechercher : Demidov, Valentin; Rechercher : Jones, Blake; Rechercher : Flueraru, Costel¹; Rechercher : Taylor, Edward; Rechercher : Alex Vitkin, I.
Affiliation	Conseil national de recherches Canada
Bailleur de fonds	Rechercher : Natural Sciences and Engineering Research Council of Canada; Rechercher : Ontario Graduate Scholarship; Rechercher : Princess Margaret Cancer Foundation; Rechercher : Terry Fox Foundation’s Strategic Training in Transdisciplinary Radiation Sciences for the 21st Century; Rechercher : Canadian Institutes of Health Research
Format	Texte, Article
Sujet	cancer imaging; cancer models; interference microscopy; predictive markers; tumour biomarkers; tumour heterogeneity
Résumé	Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical and potential therapeutic benefits as compared to conventional radiotherapy. However, its mechanism of action is yet to be fully understood, likely involving the ablation of tumour microvasculature by higher doses per fraction used in SBRT. In this study, we hypothesized that longitudinal imaging and quantification of the vascular architecture may elucidate the relationship between the microvasculature and tumour response kinetics. Pancreatic human tumour xenografts were thus irradiated with single doses of 10, 20, and 30 Gy to simulate the first fraction of a SBRT protocol. Tumour microvascular changes were monitored with optical coherence angiography for up to 8 weeks following irradiation. The temporal kinetics of two microvascular architectural metrics were studied as a function of time and dose: the diffusion-limited fraction, representing poorly vascularized tissue >150 μm from the nearest detected vessel, and the vascular distribution convexity index, a measure of vessel aggregation at short distances. These biological metrics allowed for dose dependent temporal evaluation of tissue (re)vascularization and vessel aggregation after radiotherapy, showing promise for determining the SBRT dose–response relationship.
Date de publication	2022-12
Maison d’édition	Scopus
Licence	Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/deed.fr
Dans	Scientific Reports 12, nº 1, 6140 (décembre 2022).
Langue	anglais
Publications évaluées par des pairs	Oui
Identificateur	9625
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	a79da407-703b-4f1c-8ca6-d2e1824b5d6b
Enregistrement créé	2024-02-27
Enregistrement modifié	2024-02-27

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