The fusion peptide of simian immunodeficiency virus and the phase behaviour of N-methylated dioleoylphosphatidylethanolamine

DOI	Trouver le DOI : https://doi.org/10.1016/j.bbamem.2003.09.003
Auteur	Rechercher : Harroun, Thad; Rechercher : Balali-Mood, Kia; Rechercher : Gourlay, Ian; Rechercher : Bradshaw, Jeremy
Format	Texte, Article
Sujet	biomembrane fusion; cubic phase; hexagonal phase; inhibitor; lamellar phase; small angle X-ray diffraction
Résumé	Temperature-scan X-ray scattering was used to study the effect of the fusion peptide of simian immunodeficiency virus (SIV) on the lipid polymorphism of N-methylated dioleoylphosphatidylethanolamine (DOPE-Me), in the presence and absence of one or both of the fusion inhibitors carbobenzoxy--phenylalanine--phenylalanine-glycine and 1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine (LPC). Using X-ray diffraction at stations 2.1 and 8.2 of the Synchrotron Radiation Source at Daresbury Laboratory, UK, the structure of multilamellar vesicles (MLVs) was probed as the temperature was raised from 20 to 90 ?C. The results are compared to those of similar studies, reported earlier, that used the fusion peptide of feline leukaemia virus (FeLV) which, at 28 amino acid residues in length, is considerably longer than the SIV peptide (12 amino acid residues). We interpret the results within the framework of current understanding of membrane fusion, and demonstrate how observed lipid polymorphism might describe the fusion process.
Date de publication	2003-10-08
Dans	Biochimica et Biophysica Acta (BBA) - Biomembranes 1617, nº 1-2 (8 octobre 2003) : 62–68.
Langue	anglais
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	12329001
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Identificateur de l’enregistrement	a43ff58b-ee0a-4616-a71b-9b0d37857f62
Enregistrement créé	2009-09-10
Enregistrement modifié	2020-04-02

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Date de modification :: 2026-06-09