| Téléchargement | - Voir la version finale : Engineering the Campylobacter jejuni N-glycan to create an effective chicken vaccine (PDF, 1.7 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1038/srep26511 |
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| Auteur | Rechercher : Nothaft, Harald; Rechercher : Davis, Brandi; Rechercher : Lock, Yee Ying; Rechercher : Perez-munoz, Maria Elisa; Rechercher : Vinogradov, Evgeny1; Rechercher : Walter, Jens; Rechercher : Coros, Colin; Rechercher : Szymanski, Christine M. |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Résumé | Campylobacter jejuni is a predominant cause of human gastroenteritis worldwide. Source-attribution studies indicate that chickens are the main reservoir for infection, thus elimination of C. jejuni from poultry would significantly reduce the burden of human disease. We constructed glycoconjugate vaccines combining the conserved C. jejuni N-glycan with a protein carrier, GlycoTag, or fused to the Escherichia coli lipopolysaccharide-core. Vaccination of chickens with the protein-based or E. colidisplayed glycoconjugate showed up to 10-log reduction in C. jejuni colonization and induced N-glycanspecific IgY responses. Moreover, the live E. coli vaccine was cleared prior to C. jejuni challenge and no selection for resistant campylobacter variants was observed. Analyses of the chicken gut communities revealed that the live vaccine did not alter the composition or complexity of the microbiome, thus representing an effective and low-cost strategy to reduce C. jejuni in chickens and its subsequent entry into the food chain. |
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| Date de publication | 2016-05-25 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23000027 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | a2604660-581b-4ea9-a388-6d722e601592 |
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| Enregistrement créé | 2016-05-30 |
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| Enregistrement modifié | 2020-06-02 |
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