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- Voir les données supplémentaires : Metabolic Control Analysis of triacylglycerol accumulation in oilseed rape (XLSX, 36 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1016/j.biosystems.2023.104905 |
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| Auteur | Rechercher : Fell, David A.Identifiant ORCID : https://orcid.org/0000-0001-6669-2247; Rechercher : Taylor, David C.1; Rechercher : Weselake, Randall J.; Rechercher : Harwood, John L. |
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| Affiliation | - Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Bailleur de fonds | Rechercher : Biotechnology and Biological Sciences Research Council |
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| Format | Texte, Article |
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| Sujet | Metabolic Control Analysis; Brassica napus; metabolic engineering; plant seed oil |
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| Résumé | The increasing global demand for vegetable oils will only be met if there are significant improvements in the productivity of the major oil crops, such as oilseed rape. Metabolic engineering offers the prospect of further gains in yield beyond that already achieved by breeding and selection but requires guidance as to the changes that need to be made. Metabolic Control Analysis, through measurement and estimation of flux control coefficients, can indicate which enzymes have the most influence on a desired flux. Some experiments have previously reported flux control coefficients for oil accumulation in the seeds of oilseed rape, and others have measured control coefficient distributions for multi-enzyme segments of oil synthesis in seed embryo metabolism measured in vitro. In addition, other reported manipulations of oil accumulation contain results that are exploited further here to calculate previously unknown flux control coefficients. These results are then assembled within a framework that allows an integrated interpretation of the controls on oil accumulation from the assimilation of CO₂ to deposition of oil in the seed. The analysis shows that the control is distributed to an extent that the gains from amplifying any single target are necessarily limited, but there are candidates for joint amplification that are likely to act synergistically to produce much more significant gains. |
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| Date de publication | 2023-04-24 |
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| Maison d’édition | Elsevier |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | S0303264723000801 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 9f3d22a9-61a0-4707-bc7f-c475af96f9be |
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| Enregistrement créé | 2023-08-09 |
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| Enregistrement modifié | 2023-08-09 |
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